Dynein and dynein-related genes
نویسندگان
چکیده
منابع مشابه
Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions*
A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice. The mechanism by which the Loa mutation impairs the neuron-specific functions of dynein is not understood...
متن کاملCytoplasmic dynein.
The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's me...
متن کاملDynein Structure and Function
The structure of dynein isolated from several sources follows the pattern first observed with Tetrahymena 22 S dynein, which has three globular heads attached by three flexible strands to a root-like base. Recent biochemical data indicate that there is one ATPase site on each dynein head and that all three heads interact with microtubules in an ATP-sensitive manner. Accordingly, images of dynei...
متن کاملCytoplasmic dynein nomenclature
A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes. We propose names for the mammalian cytoplasmic dynein subunit genes and proteins that refl...
متن کاملDynein takes its vimentin
ove over, vesicles. Intermediate filaments (IFs) are also a major cargo of microtubule-based motor proteins, according to new results from Helfand et al. on page 795. The results M explain how rapid changes in IF structure are produced by transport of nonfilamentous vimentin particles. Dynamic changes in vimentin IF structure occur at the onset of cell spreading, requiring the transport of vime...
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ژورنال
عنوان ژورنال: Cell Motility and the Cytoskeleton
سال: 1998
ISSN: 0886-1544,1097-0169
DOI: 10.1002/(sici)1097-0169(1998)39:4<261::aid-cm2>3.0.co;2-6